The Log-Rank test is a non-parametric hypothesis test used to compare the survival distributions of two or more groups. It is particularly useful in clinical trials, medical research, and reliability engineering to determine if there is a statistically significant difference in the time-to-event outcomes between different interventions, treatments, or conditions. The 'event' can be death, disease recurrence, component failure, or any other binary outcome of interest.
Core Concept of Survival Analysis
Survival analysis focuses on the expected duration of time until an event occurs. A key feature of this analysis is 'censoring'. Censoring happens when the event of interest has not occurred for a subject by the end of the study, or if the subject is lost to follow-up. The Log-Rank test is designed to correctly handle censored data in its calculations.
The Role of Hypothesis Testing
Like other hypothesis tests, the Log-Rank test starts with a null hypothesis (H₀) and an alternative hypothesis (H₁). The null hypothesis states that there is no difference in the survival distributions between the groups being compared. The alternative hypothesis states that there is a difference. The test calculates a p-value, which helps decide whether to reject the null hypothesis.
Key Assumptions of the Test
The primary assumption of the Log-Rank test is that the hazard rates of the two groups are proportional over time. This means that the ratio of the hazard rates is constant. If the survival curves cross, this assumption may be violated, and other tests like the Wilcoxon test might be more appropriate. Additionally, it assumes that censoring is non-informative, meaning the reasons for censoring are unrelated to the event of interest.